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Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

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Presentation on theme: "Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent."— Presentation transcript:

1 Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent vasodilatation  Roger J. Laham, MD, Michael Simons, MD, Motohisa Tofukuji, MD, PhD, David Hung, MD, PhD, Frank W. Sellke, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 116, Issue 6, Pages (December 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Myocardial vascular resistance in the normal (LAD) and collateral-dependent (LCX) territories at 3 weeks. Four weeks after intrapericardial drug delivery, vascular resistance in the collateral-dependent LCX territory was lower in bFGF-treated animals than in control animals. Data are shown as mean ± standard deviation. *Statistical significance (P < .0017) compared with LAD at 3 weeks and LCX final compared with LCX at 3 weeks. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Endothelium-independent (SNP, A) and endothelium-dependent (ADP, B) vasodilatation in the normal (LAD) myocardium. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Endothelium-independent (SNP, A) and endothelium-dependent (ADP, B) vasodilation in the collateral-dependent LCX myocardium showing preserved response to SNP with impaired response to ADP, restored by bFGF treatment. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Expression of iNOS and eNOS in ischemic and normal myocardium by reverse transcriptase–polymerase chain reaction (RT-PCR) and Western analysis. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

6 Fig. 5 Endothelium-dependent vasodilatation (ADP) was not affected by the presence of 2 different concentrations (10–6 and 10–7 mol/L) of SNP, an NO donor. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

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