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Darshi et al. Am J Nephrol 2016;44: (DOI: / )

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1 Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer
Darshi et al. Am J Nephrol 2016;44: (DOI: / ) Table 1. A comparison of GC-MS, LC-MS and NMR technologies in metabolomics 

2 Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer
Darshi et al. Am J Nephrol 2016;44: (DOI: / ) Table 2. Summary of metabolites affected in DKD identified by clinical metabolomic analysis

3 Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer
Darshi et al. Am J Nephrol 2016;44: (DOI: / ) Table 3. Summary of metabolomic alterations in animal models of DKD

4 Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer
Darshi et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 1. Overview of urinary metabolite changes in TCA cycle, fatty acid and amino acid metabolism, and affected enzymatic pathways in DKD clinical and preclinical studies. MPC = Mitochondrial pyruvate carrier; PDH = pyruvate dehydrogenase complex; IDH = isocitric dehydrogenase; α-KGDH = alpha ketoglutarate dehydrogenase. Metabolites associated with clinical studies are indicated with red arrows and preclinical studies with blue arrows. 


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