1. Structure of an exporter.
Structure of an exporter. Sav1866 is a homodimer of two IM-ABC subunits. IM domain 1 (green) is fused to NBD1 (blue), and IM domain 2 (red) is fused to NBD2 (yellow). Bound ADP is represented with a ball-and-stick model. The front view (left) reveals a cleft in the IM region that would be exposed to the outer leaflet of the lipid bilayer. TM helices are predicted to extend well into the cytoplasm, creating an ICD. The side view (right) reveals the intertwisting of TM helices that places the coupling helix of one subunit into the cleft of the NBD of the second subunit in an example of domain swapping.
Amy L. Davidson et al. Microbiol. Mol. Biol. Rev. 2008; doi: /MMBR