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Antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against xenograft models sensitive.

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Presentation on theme: "Antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against xenograft models sensitive."— Presentation transcript:

1 Antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against xenograft models sensitive to temozolomide (GBM2, Rh28, MGMT-deficient), or single-agent talazoparib (KT-10), and two additi... Antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against xenograft models sensitive to temozolomide (GBM2, Rh28, MGMT-deficient), or single-agent talazoparib (KT-10), and two additional alveolar rhabdomyosarcoma xenografts (Rh30, Rh41). Combination A (temozolomide 30 mg/kg for 5 days; talazoparib 0.1 mg/kg twice daily for 5 days); combination B (temozolomide 12 mg/kg for 5 days; talazoparib 0.25 mg/kg twice daily for 5 days). Graphs show growth of individual tumors in SCID mice. Malcolm A. Smith et al. Clin Cancer Res 2015;21: ©2015 by American Association for Cancer Research

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