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Knockdown of PKM2 suppressed TPA-induced skin cell transformation.

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Presentation on theme: "Knockdown of PKM2 suppressed TPA-induced skin cell transformation."— Presentation transcript:

1 Knockdown of PKM2 suppressed TPA-induced skin cell transformation.
Knockdown of PKM2 suppressed TPA-induced skin cell transformation. JB6 P+ cells were used for the experiments. A, the expression levels of PKM2 were detected in siRNA-transfected cells by Western blot analysis. SDHB served as the loading control. B, soft agar colony formation assay was conducted using siRNA-transfected cells. Ctrl/D, control siRNA plus DMSO treatment; PKM2/D, PKM2 siRNA plus DMSO treatment; Ctrl/T, control siRNA plus TPA (5 nmol/L) treatment; PKM2/T, PKM2 siRNA plus TPA treatment. *, P < 0.05 compared with the control siRNA/DMSO group; #, P < 0.05 compared with the control siRNA/TPA group. Jennifer A. Wittwer et al. Cancer Prev Res 2011;4: ©2011 by American Association for Cancer Research

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