1. Cell Mediated Immunity
Introduction
Cytokines
Components of Cell Mediated Immunity

2. Cell Mediated Immunity
Introduction
Involves specialized lymphocytes call T-cells
T-cells mature in thymus
Response to intracellular viruses, multicellular parasites, transplanted tissues and cancer

3. Cell Mediated Immunity
Cytokines are chemical messengers
Interleukins are cytokines that allow leukocytes to communicate
Interferons are cytokines that protect against viruses
Chemokines cause leukocytes to move to site of infection

4. Cell Mediated Immunity
Components
Helper T Cells (TH )
Cytotoxic T Cells (TC )
Delayed Hypersensitivity T Cells (TD)
Suppressor T Cells (TS)
Activated Macrophages
Natural Killer Cells

5. Cell Mediated Immunity
Helper T Cells
Activate B-cells
Activate cytotoxic T cells
Activate other helper T cells

6. Cell Mediated Immunity
Cytotoxic T Cells
Used to attack intracellular pathogens such as viruses, some bacteria, multicellular parasites
Attaches to target cell
Releases protein perforin which pokes holes in target cell inducing lysis
T cells continue as long as antigen is present

7. Cell Mediated Immunity
Delayed Hypersensitivity T Cells
Involved in allergic reactions like response to poison ivy and transplanted tissue rejection
Originally named because transfer of cell transferred immunity to TB
Probably a subpopulation TH cells and TC cells

8. Cell Mediated Immunity
Suppressor T Cells
Appears to regulate immune response
Probably a subpopulation of helper cells

9. Cell Mediated Immunity
Activated Macrophages
Stimulated by ingestion antigens and cytokines from helper T cells
Acquire enhanced ability to digest via phagocytosis virus infected cells and intracellular bacteria infected cells
Can be antigen presenting cells

10. Cell Mediated Immunity
Nautral Killer Cells
Kill virus infected cells, tumor cells and large parasites
Not immunologically specific like cytotoxic T cells