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Risk ratio (RR) and number needed to treat (NNT) are time-dependent measures. a) When an intervention is associated with constant relative risk reduction over time, the NNT progressively decreases as the number of events increases; b) conversely, when the a... Risk ratio (RR) and number needed to treat (NNT) are time-dependent measures. a) When an intervention is associated with constant relative risk reduction over time, the NNT progressively decreases as the number of events increases; b) conversely, when the absolute risk reduction remains constant over time, the relative risk reduction progressively decreases (increased relative risk). Annie C. Lajoie et al. Eur Respir Rev 2018;27:180020 ©2018 by European Respiratory Society
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