1. A, the effect of rh-Matrilysin (100 units/ml) or HGF/SF (60 ng/ml) on colony scattering in LNCapFGC cells after incubation at 37°C for up to 7 h.
A, the effect of rh-Matrilysin (100 units/ml) or HGF/SF (60 ng/ml) on colony scattering in LNCapFGC cells after incubation at 37°C for up to 7 h. There was a significant difference in scattering index as determined by area morphometry after 30 min exposure to either rh-Matrilysin (P = 0.008) or HGF/SF (P = 0.021), respectively, using the means from 10 colonies per time point; bars, SE. B, the invasive capacity of LNCapFGC cells through basement membrane Matrigel was significantly enhanced by inclusion of either 100 units/ml of rh-Matrilysin (P = ) or 40 ng/insert of HGF/SF (P = ), respectively, after 96 h of culture at 37°C. Bars, SE.
Gaynor Davies et al. Clin Cancer Res 2001;7:
©2001 by American Association for Cancer Research