1. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults 
Somnath Mukhopadhyay, FRCPCH, MD, PhD, Joseph Sypek, PhD, Roger Tavendale, PhD, Ulrike Gartner, PhD, John Winter, FRCP, Wei Li, PhD, Karen Page, PhD, Margaret Fleming, PhD, Jeff Brady, PhD, Margot O'Toole, PhD, Donald F. Macgregor, FRCPCH, Samuel Goldman, PhD, Steve Tam, PhD, William Abraham, MD, Cara Williams, PhD, Douglas K. Miller, PhD, Colin N.A. Palmer, PhD 
Journal of Allergy and Clinical Immunology 
Volume 126, Issue 1, Pages e16 (July 2010)
DOI: /j.jaci
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
A-C, The MMP12 serine 357 variant is associated with clinically worse asthma with relation to increasing inhaled β2-agonist use (Fig 1, A), asthma treatment step (Fig 1, B), and risk of asthma exacerbations over 6 months (Fig 1, C; P for χ2 analysis trend). D, Increasing medication use positively correlates with exacerbation risk, implying that current treatment regimens are inadequate overall for effective asthma control.
Journal of Allergy and Clinical Immunology  , e16DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
MMP-12 inhibition by MMP408 reduced total bronchoalveolar lavage inflammation (A), airway resistance (0-8 hours; B and C), and carbachol responsiveness (24 hours; D and E) after A suum antigen challenge in sheep (MMP408 dose: Fig 2, A, B, and D, 10 mg/kg administered intravenously; Fig 2, C and E, 10 mg/kg administered orally). Graphs represent group means ± SEMs. ∗P < .05, 5 animals per group, Student paired t test versus test control subjects.
Journal of Allergy and Clinical Immunology  , e16DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Linkage disequilibrium relationship of haplotype-tagging SNPs across the MMP12 locus. Visualized with Haploview V4.1: Hap Map CEU Phase 2 Release 21. CEU genotypes. The R2 values are shown from the CEU dataset.
Journal of Allergy and Clinical Immunology  , e16DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions