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The Power of Strain: Organizing Left-Right Cilia

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Presentation on theme: "The Power of Strain: Organizing Left-Right Cilia"— Presentation transcript:

1 The Power of Strain: Organizing Left-Right Cilia
Martin Blum, Tim Ott  Developmental Cell  Volume 45, Issue 3, Pages (May 2018) DOI: /j.devcel Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of Mechanical Strain in Xenopus Left-Right Development Foxj1 expression in the gastrula embryo (A) marks the superficial mesoderm (SM; B, B’), from which the left-right organizer (LRO; C) develops when the SM involutes during gastrulation. Convergent extension movements during involution exert graded mechanical strain (D), along which cilia lengthen, become motile, and polarize (E). The ensuing leftward flow is sensed by lateral LRO cells, which harbor immotile and non-polarized cilia that express nodal1 (blue) and its inhibitor dand5 (yellow). Dand5 is inhibited by flow (E), resulting in Nodal cascade induction in the left lateral plate mesoderm (F) and asymmetric organ morphogenesis of the tadpole (G). Arrowheads, dorsal lip. A, anterior; l, left; r, right; p, posterior. Image provided by Jennifer Kreis. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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