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Figure 1 Toxic factors are enriched in Ex-En fractions prepared from MS B-cell Sup by water exclusion precipitation Toxic factors are enriched in Ex-En.

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Presentation on theme: "Figure 1 Toxic factors are enriched in Ex-En fractions prepared from MS B-cell Sup by water exclusion precipitation Toxic factors are enriched in Ex-En."— Presentation transcript:

1 Figure 1 Toxic factors are enriched in Ex-En fractions prepared from MS B-cell Sup by water exclusion precipitation Toxic factors are enriched in Ex-En fractions prepared from MS B-cell Sup by water exclusion precipitation B-cell Sup from 5 MS and 5 NC were centrifuged at 2,000g for 30 minutes to remove cell debris; medium alone was processed in parallel as control. The supernatants were removed for isolation of Ex-En fractions; the pellets were suspended and tested for OL toxicity. The supernatants were mixed with isolation reagent. Samples were incubated at 4° overnight and then centrifuged at 10,000g for 1 hour. The exosome-enriched precipitates, designated Ex-En, were tested for OL toxicity. The background value for NC Ex-En and MS Ex-En toxicity is the value for the toxicity of the medium Ex-En fraction (19%); subtraction of that value gives a range of −2% to 13% for NC Ex-En and a range of 37%–43% for MS Ex-En. Values represent averages, n = 2 ± range; *p < by analysis of variance with the Tukey post-test. Ex-En = exosome enriched; NC = normal control; OL = oligodendrocyte. Joyce A. Benjamins et al. Neurol Neuroimmunol Neuroinflamm 2019;6:e550 Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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