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BH3 profiling predicts venetoclax sensitivity in primary BPDCNs

Published byInga Mikalsen Modified over 5 years ago

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Presentation on theme: "BH3 profiling predicts venetoclax sensitivity in primary BPDCNs"— Presentation transcript:

1 BH3 profiling predicts venetoclax sensitivity in primary BPDCNs
BH3 profiling predicts venetoclax sensitivity in primary BPDCNs. A, Basal BH3 profiling showing cytochrome c release in response to 100 μmol/L BAD peptide stimulation (normalized to DMSO control) in primary BPDCNs from patients and from PDXs, AMLs, and norm... BH3 profiling predicts venetoclax sensitivity in primary BPDCNs. A, Basal BH3 profiling showing cytochrome c release in response to 100 μmol/L BAD peptide stimulation (normalized to DMSO control) in primary BPDCNs from patients and from PDXs, AMLs, and normal bone marrow (NBM). B, Basal BH3 profiling in response to 1 μmol/L venetoclax, as in A. C, Dynamic BH3 profiling depicting the difference in overall apoptotic priming before and after exposure to 100 nmol/L venetoclax for 4 hours. D, Correlation of dynamic BH3 profiling delta priming with percent cell death by Annexin V flow cytometry (Spearman r and P values for correlation are shown). Joan Montero et al. Cancer Discov 2017;7: ©2017 by American Association for Cancer Research

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