1. Linear correlationa between TMB cutoff for ORb for CR/PR rates and HRc for PFS, and OS depending on TMB for patients treated with anti-PD-1/PD-L1 monotherapy (N = 102).
Linear correlationa between TMB cutoff for ORb for CR/PR rates and HRc for PFS, and OS depending on TMB for patients treated with anti-PD-1/PD-L1 monotherapy (N = 102). A, OR for CR/PR rate depending on TMB cutoff (R2 = , P = , Y = X ). B, HR for PFS depending on TMB cutoff (R2 = , P = , Y = − X ). C, HR for OS depending on TMB cutoff (R2 = , P = , Y = − X ). a, Linear regression performed using the least squares method. b, OR >1.0 implies higher chance of response. The OR was calculated by comparing RR above and below the cut-off for each value. c, HR < 1.0 implies less chance of progression or death. The HR was evaluated by comparing OS above and below the cut-off for each value. CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.
Aaron M. Goodman et al. Mol Cancer Ther 2017;16:
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