1. Representative macrophage staining images only from the knee joints of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.
Representative macrophage staining images only from the knee joints of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA. The two panels from left to right (A and B) show IHC macrophage staining using anti-F4/80 Ab (red color) from the knee joints of CAIA mice treated with GalNAc–luciferase–siRNA (left panel) or with GalNAc–MASP-3–siRNA duplex 2 (right panel). The two panels are showing the enhanced (original magnification ×20) red boxed area of the synovium for clarity. Areas of synovium (S, arrow), cartilage (C, arrow), bone marrow (BM, arrow), and meniscus (M, arrow) are identified. The sections were photographed at original magnification ×10. Scale bars shown in red in the bottom right of each panel for knee joint, original magnification ×20, 0.05 mm (50 μm), and original magnification ×10, 0.1 mm (100 μm).
Nirmal K. Banda et al. ImmunoHorizons 2018;2:
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