1. Modeling of EGFR exon 20 insertions using the 3-dimensional structure of the EGFR kinase domain predicts different interactions with the erlotinib-binding region.
Modeling of EGFR exon 20 insertions using the 3-dimensional structure of the EGFR kinase domain predicts different interactions with the erlotinib-binding region. The X-ray structure at 2.6 Å resolution (PDB code 1M17) is used to show the drug and the positions of mutations. Yellow, C helix; green, erlotinib; labeled residues identify the region of the insertion.
Maria E. Arcila et al. Mol Cancer Ther 2013;12:
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