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Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients  Christine L Lau, MD, Scott M Palmer, MD, Katherine E.

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Presentation on theme: "Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients  Christine L Lau, MD, Scott M Palmer, MD, Katherine E."— Presentation transcript:

1 Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients 
Christine L Lau, MD, Scott M Palmer, MD, Katherine E Posther, BA, David N Howell, MD, PhD, Nancy L Reinsmoen, PhD, H.Todd Massey, MD, Victor F Tapson, MD, James J Jaggers, MD, Thomas A D’Amico, MD, R.Duane Davis, MD  The Annals of Thoracic Surgery  Volume 69, Issue 5, Pages (May 2000) DOI: /S (00)

2 Fig 1 Kaplan-Meier comparison of survival between high and low PRA.
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

3 Fig 2 Immunohistochemical staining for complement (C3) showing deposition in a pattern outlining capillary walls from a patient with a high PRA. This staining is evidence of humoral-mediated lung injury. The Annals of Thoracic Surgery  , DOI: ( /S (00) )

4 Fig 3 Histopathologic examination of biopsy from same patient as Figure 2 showing marked alveolar capillaritis accompanied by endothelial swelling and margination of inflammatory cells (hematoxylin and eosin, ×520). The Annals of Thoracic Surgery  , DOI: ( /S (00) )

5 Fig 4 Proposed treatment scheme for lung transplant recipients with elevated pretransplant PRA. The Annals of Thoracic Surgery  , DOI: ( /S (00) )

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