1. Regulation of intestinal health by antigen presentation.
Regulation of intestinal health by antigen presentation. Microbiota are sampled by intestinal Zbtb46+ conventional DCs (cDCs), and bacteria-loaded cDCs then migrate to the draining mesenteric lymph nodes and activate naïve CD4+ T cells by presenting commensal bacteria–derived antigen via MHC-II, resulting in the differentiation of effector and regulatory microbiota–specific CD4 T cells. MHC-II+ RORγt+ ILC3s contact antigen-experienced T effector cells, resulting in deletion of commensal bacteria–specific CD4+ effector T cells, a process termed intestinal selection. In addition, activated CD4+ T cells partly differentiate into Treg cells, which migrate to lamina propria and regulate intestinal homeostasis. Essential pathways that prevent spontaneous inflammation are highlighted in red.
Lei Zhou, and Gregory F. Sonnenberg Sci. Immunol. 2018;3:eaao1605
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