1. IL-1β Activation as a Response to Metabolic Disturbances
Marc Y. Donath, Marianne Böni-Schnetzler 
Cell Metabolism 
Volume 12, Issue 5, Pages (November 2010)
DOI: /j.cmet
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1
Activation of IL-1β in Islets of Patients with Type 2 Diabetes
Glucose, free fatty acids (FFA), and adipokine (leptin) promote β cell production of IL-1β. In turn, IL-1β induces the production and release of a wide panel of cytokines and chemokines, which recruit macrophages. Human islet polypeptide will then activate the macrophage NALP3 inflammasome, enhancing IL-1β production. IL-1β will also induce itself initiating a vicious cycle.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2010 Elsevier Inc. Terms and Conditions