1. Volume 142, Issue 7, Pages 1414-1416 (June 2012)
Self-Renewal of Tumor-Initiating Cells: What's New About Hepatocellular Carcinoma? 
Anna Alisi 
Gastroenterology 
Volume 142, Issue 7, Pages (June 2012)
DOI: /j.gastro
Copyright © 2012 AGA Institute Terms and Conditions

2. Figure 1
Proposed model for liver T-IC–mediated hepatocarcinogenesis. Tumorigenicity and metastatic potential of liver T-ICs depend on the acquisition of specific traits: switch from quiescence to proliferation, self-renewal, differentiation ability, and infiltrative capacity that may lead to development of a chemoresistant and metastatic HCC. As explained in the text, several cell-surface markers, pathways and fate-determining regulatory factors may be involved in the acquisition of these traits.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions