1. EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer
A, BqRT–PCR of mRNA from T47D transfected with either EglN2 siRNA (1, 4) (A) or NRF1 pool siRNA (B) under normoxia. CqRT–PCR of mRNA from T47D with or without hypoxia (5% O2) treatment. DqRT–PCR of mRNA from T47D cells transfected with either PGC‐1α siRNAs (1, 2, 3, and 4) or control (Ctrl) followed by hypoxia (5% O2) treatment for 16 h. EFDXR regulates ERα‐positive breast tumorigenesis. Unpaired two‐sample t‐test comparing expression of FDXR in the TCGA dataset between the indicated patients. Data information: Two‐tailed Student's t‐test was used to examine the P‐values from at least three replicate experiments. Error bars represent SEM. *P < 0.05, **P < 0.01, ***P < 0.005.
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EMBO J, Volume: 34, Issue: 23, Pages: , First published: 22 October 2015, DOI: ( /embj )