1. Genotype–Phenotype Relationships in Hepatocellular Carcinoma: p53 Inactivation Promotes Tumors With Stem Cell Features 
Jean–Charles Nault, Jessica Zucman–Rossi 
Gastroenterology 
Volume 142, Issue 5, Pages (May 2012)
DOI: /j.gastro
Copyright © 2012 AGA Institute Terms and Conditions

2. Figure 1
p53 inactivation at initiation step in liver carcinogenesis. Mice with liver-specific p53 disruption developed HCC harboring chromosomal instability and bilineal features. Both mature hepatocytes and liver stem cells purified from p53−/− livers are able to give rise to HCC tumors with stem cell-like markers. Additional inactivation of the retinoblastoma (Rb) pathway participates in tumor development and increases its agressivity.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions