1. Tipifarnib combined with bortezomib induces cell death in diverse multiple myeloma and AML cell lines.
Tipifarnib combined with bortezomib induces cell death in diverse multiple myeloma and AML cell lines. H929 (A), U266 (B), MM1s (C), or KG-1 (D) cell lines were treated with the indicated concentrations of tipifarnib, bortezomib, or the combination for 24 hours in cell suspension. Cell death was determined by flow cytometry after Annexin V/FITC and propidium iodide staining. Specific cell death was calculated relative to untreated controls. Three independent experiments. To identify evidence for greater than additive effect, a simple linear regression (no intercept model) was used that included drug effect for each individual drug and the interaction effect of the combination. SAS software was used in the calculations using Proc REG (n = 9 observations for each cell line). Ps are provided. Columns, mean; bars, SE.
Niranjan Yanamandra et al. Clin Cancer Res 2006;12:
©2006 by American Association for Cancer Research