Presentation is loading. Please wait.

Presentation is loading. Please wait.

MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification.

Published byRhoda Osborne Modified over 5 years ago

Similar presentations

Presentation on theme: "MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification."— Presentation transcript:

1 MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. FISH analysis showing amplification of the MET gene in formalin-fixed paraffin embedded (FFPE) tissue sections from 3 patients with colorectal cancer (#1, #2, and #3; A–C) who developed resistance to therapy with the anti-EGFR monoclonal antibodies panitumumab (Pmab) or cetuximab (Cmab). MET (7q31)–specific probe is labeled with Texas red, whereas chromosome 7 centromeric probe D7Z1 (7p11.1–q11.1) is marked in green. IHC staining for MET is shown in the left of each panel. FISH, original magnification ×60; IHC, original magnification ×40. Alberto Bardelli et al. Cancer Discovery 2013;3: ©2013 by American Association for Cancer Research

Download ppt "MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification."

Similar presentations

KRAS testing in colorectal cancer

KRAS testing in colorectal cancer
Fluorescent In Situ Hybridization (FISH) to Identify Genetic Changes in Fine Needle Biopsy of Lung Lesions Prepared by Jin Jen NCI.

Fluorescent In Situ Hybridization (FISH) to Identify Genetic Changes in Fine Needle Biopsy of Lung Lesions Prepared by Jin Jen NCI.
Fig. 1. EGFR content as determined by fluorescence in situ hybridization (FISH) and immunohistochemical staining. FISH was performed with the EGFR ( red.

Fig. 1. EGFR content as determined by fluorescence in situ hybridization (FISH) and immunohistochemical staining. FISH was performed with the EGFR ( red.
Figure S1 a b c d DAPI Lgr β-catenin Merge

Figure S1 a b c d DAPI Lgr β-catenin Merge
Testing algorithm integrating diagnostic and predictive analysis in nonsmall cell lung cancer (NSCLC). Testing algorithm integrating diagnostic and predictive.

Testing algorithm integrating diagnostic and predictive analysis in nonsmall cell lung cancer (NSCLC). Testing algorithm integrating diagnostic and predictive.
Simultaneous Detection of Clinically Relevant Mutations and Amplifications for Routine Cancer Pathology  Marlous Hoogstraat, John W.J. Hinrichs, Nicolle.

Simultaneous Detection of Clinically Relevant Mutations and Amplifications for Routine Cancer Pathology  Marlous Hoogstraat, John W.J. Hinrichs, Nicolle.
AZD9291 inhibits EGFR phosphorylation and downstream signaling in murine models of EGFRT790M-resistant lung cancer. AZD9291 inhibits EGFR phosphorylation.

AZD9291 inhibits EGFR phosphorylation and downstream signaling in murine models of EGFRT790M-resistant lung cancer. AZD9291 inhibits EGFR phosphorylation.
Rearrangements of Gene A and Gene B

Rearrangements of Gene A and Gene B
Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe–Based Single-

Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe–Based Single-
(A) Timeline of the patient’s clinical events and interventions.

(A) Timeline of the patient’s clinical events and interventions.
Immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) analysis of MET and KRAS. For IHC, the specific MET antibody (Met (D1C2) XP Rabbit.

Immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) analysis of MET and KRAS. For IHC, the specific MET antibody (Met (D1C2) XP Rabbit.
Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities.

Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities.
Simultaneous Detection of Clinically Relevant Mutations and Amplifications for Routine Cancer Pathology  Marlous Hoogstraat, John W.J. Hinrichs, Nicolle.

Simultaneous Detection of Clinically Relevant Mutations and Amplifications for Routine Cancer Pathology  Marlous Hoogstraat, John W.J. Hinrichs, Nicolle.
PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.
Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.

Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.
Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.

Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.
IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).
Predictive biomarker analyses in cytological specimens

Predictive biomarker analyses in cytological specimens
Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Similar presentations

Ads by Google