1. Back to the Roots: Deep View into the Evolutionary History of ADP-Ribosylation Opened by the DNA-Targeting Toxin-Antitoxin Module DarTG 
Alexander Harms, Kenn Gerdes 
Molecular Cell 
Volume 64, Issue 6, Pages (December 2016)
DOI: /j.molcel
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Tightly Controlled ADP-Ribosylation of Single-Stranded DNA by the DarTG Toxin-Antitoxin Module
Jankevicius et al. (2016) demonstrate that the DarT toxin ADP-ribosylates single-stranded DNA and thereby abrogates chromosome replication and bacterial growth. The DarG antitoxin reverses these effects through hydrolysis of the ADP-ribosylation and seems to exert an additional layer of control by directly blocking the enzymatic activity of DarT through direct protein-protein interactions. Biological functions of the DarTG toxin-antitoxin module remain elusive, but the authors speculate that it may act in bacterial persistence or in conjunction with restriction-modification systems.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2016 Elsevier Inc. Terms and Conditions