1. Shift in the perspective of mucosa-associated microbial communities from the culture era to the sequencing era in healthy and CRS states.
Shift in the perspective of mucosa-associated microbial communities from the culture era to the sequencing era in healthy and CRS states. (A) Previous culture-based assessments of sinonasal-associated microbiology in healthy subjects led to the view of the sinuses as being a predominantly sterile site and identified a relatively simple bacterial community associated with the nasal cavity. (B) Early culture-based assessment of CRS patients highlighted the possible role of putative bacterial and fungal pathogens in the development or progressive course of CRS. (C and D) Sequencing-era assessment of the microbiota subsequently identified markedly more diverse microbial communities associated with both healthy (C) and CRS (D) states, with little consensus emerging on unique associations with CRS.
Michael Hoggard et al. Clin. Microbiol. Rev. 2017; doi: /CMR