1. Irradiated whole-cell vaccination with MOC1, but not MOC2, induces immunologic memory.
Irradiated whole-cell vaccination with MOC1, but not MOC2, induces immunologic memory. A, 1 × 106 untreated or irradiated MOC1 cells were injected into WT B6 mice in complete Freund's adjuvant (left, n = 10 mice/group). Four weeks later, 2 × 106 untreated MOC1 cells were injected into separate cohorts of naïve and vaccinated mice (middle). Vaccinated mice that did not engraft tumors following MOC1 challenge (9 of 10 challenged mice) were rechallenged with 1 × 105 MOC2 cells (right). B, 1 × 105 untreated or 1 × 106 irradiated MOC2 cells were injected into WT B6 mice (left). Vaccinated or control WT B6 mice were then challenged with 1 × 105 MOC2 cells (right). Rates of engraftment are shown below each plot. P values were calculated using the Fisher exact test. Growth curves shown are representative of two series of independent experiments with similar results.
Ellen Moore et al. Cancer Immunol Res 2016;4:
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