1. The effects of high-stretch tidal ventilation with an oxygen concentration of either 21 or 90% on surfactant proteins (SP-A to SP-D) at the mRNA level (signifier for surfactant protein production).
The effects of high-stretch tidal ventilation with an oxygen concentration of either 21 or 90% on surfactant proteins (SP-A to SP-D) at the mRNA level (signifier for surfactant protein production). A: Non-stretched lungs. B: High-stretched lungs. Excessive stretch in a hyperoxic environment inhibited surfactant function in this experiment (including reduced lung compliance), in part illustrated by reduced mRNA levels for producing these proteins. Both SP-B and SP-C are associated with maintaining alveolar stability, whereas SP-A and SP-D are part of the innate immune system and protect against bacterial, fungal, and viral infection.37 This suggests that stretch-related injury in conjunction with hyperoxia enhances lung instability and susceptibility to pulmonary and systemic infection. Data are shown as mean values. Data from Reference 28.
Richard H Kallet, and Richard D Branson Respir Care 2016;61:
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