1. Depressed Mood Disorders and Disturbances ≤3.1%
Varenicline
Bupropion
Placebo
Incidence
(%)
95% CI
DMDD, all
2.8
3.1
1.8
DMDD, drug-related
1.2 –
2.3
1.1

2. Psychiatric AEs >1% Psychiatric Adverse Events Varenicline
Bupropion
Placebo
Incidence
(%)
95% CI
Anxiety disorders and symptoms
4.6
3.8, 5.5
8.3
6.5, 10.4
5.1
4.1, 6.3
Changes in physical activity (bruxism, restlessness)
1.1
0.7, 1.6
2.0
1.2, 3.2
1.0
0.6, 1.6
Mood disorders and disturbances
2.3
1.8, 3.0
1.6
1.1, 2.4