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Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping by Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo,

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Presentation on theme: "Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping by Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo,"— Presentation transcript:

1 Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping
by Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, and Takao Someya Science Volume 4(10):eaau2426 October 19, 2018 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

2 Fig. 1 Stretchable OECT array on honeycomb grid substrate.
Stretchable OECT array on honeycomb grid substrate. (A) Image of the stretchable electrophysiology OECT array on a honeycomb grid parylene substrate. (B) Cross section of the stretchable OECT array. (C) A 4 × 4 stretchable OECT array when intrinsically stretched. Scale bar, 3 mm. (D) Magnified view of 4 × 4 stretchable OECT array when stretched. Scale bar, 500 μm. Wonryung Lee et al. Sci Adv 2018;4:eaau2426 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

3 Fig. 2 Electrical and mechanical characteristics of stretchable OECTs.
Electrical and mechanical characteristics of stretchable OECTs. (A) Ids-Vgs curve of OECTs in 4 × 4 stretchable OECT array (fig. S3). The channel width and length were 10 and 15 μm, respectively. (B) Distribution of transconductance in a 4 × 4 stretchable OECT array. (C) Drain current (Ids) − gate voltage (Vgs) curve of single OECT (fig. S5) after 0, 5, 10, and 15% stretching. Inset: Microscope image of single OECTs, which were intrinsically 10% stretched. Scale bar, 200 μm. The channel width and length were 10 and 15 μm, respectively. (D) Normalized value of Ids and transconductance (gm) at Vg = 0 V after 15% stretching with the number of cycling. Wonryung Lee et al. Sci Adv 2018;4:eaau2426 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

4 Fig. 3 Blood compatibility evaluation of PMC3A coating on OECTs.
Blood compatibility evaluation of PMC3A coating on OECTs. (A) SEM image of PET- and PMC3A-coated film after 1 hour of platelet adhesion. Scale bar, 10 μm. (B) Number of adhered platelets on PET, PEDOT:PSS, and PMC3A films after 1 hour of platelet adhesion. (C) Comparison of normalized ΔIds of OECTs without PMC3A coating with a Vgs pulse width of 30 ms after 0.1, 0.2, 0.5, 1, and 2 hours of platelet adhesion. ΔIds is defined as [Ids − Ids(Vg=0V)]. The normalization of ΔIds was conducted by maximum ΔIds at 100 mV of Vgs before platelet adhesion [ΔIds(Max at 0h, Vg=100 mV)]. (D) Comparison of the normalized ΔIds of OECTs with PMC3A coating with a Vgs pulse width of 30 ms after 0.1, 0.2, 0.5, 1, and 2 hours of platelet adhesion. ΔIds is defined as [Ids − Ids(Vg = 0 V)]. The normalization of ΔIds was conducted by the maximum value of ΔIds at 100 mV of Vgs before platelet adhesion [ΔIds(Max at 0h, Vg=100 mV)]. Wonryung Lee et al. Sci Adv 2018;4:eaau2426 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

5 Fig. 4 In vivo recording on the heart of a rat.
In vivo recording on the heart of a rat. (A) Photograph of the stretchable OECT array on the heart of a rat. Scale bar, 5 mm. (B) Recorded ECG by stretchable OECT array without PMC3A coating. (C) Recorded ECG by stretchable OECT array with PMC3A coating. (D) Image of the positioning of the 4 × 4 OECT array on the heart of a rat. (E) ECG signals from multiplexed 4 × 4 OECT array. The drain voltage of each channel was −0.3 V. (F) Time delay of ECG signals. Data were changed by transconductance of each OECT. Wonryung Lee et al. Sci Adv 2018;4:eaau2426 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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