1. Replication stress inhibition synergizes with DNA damaging agents in human cells.
Replication stress inhibition synergizes with DNA damaging agents in human cells. A, Synergy scores of the combination matrix of cisplatin and the ATR inhibitor VE-822 tested in a panel of 6 human SCLC cell lines. B, Synergy score of the combination of cisplatin and VE-822 tested on primary human fibroblasts. All synergy scores were calculated using the MAC Synergy II algorithm using data from three independent experiments. C, Comparison of the synergy volumes of a panel of 6 SCLC and 6 NSCLC cell lines. Synergy volumes were obtained from the experiments represented in Fig. 3A and Supplementary Fig. S2C. Statistical significance was calculated using a Student t test.
Remco Nagel et al. Mol Cancer Ther 2019;18:
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