1. HPV–human protein network map.
HPV–human protein network map. Network representation of the HPV–human interaction map in C33A cells ( see also Supplementary Table S2). Diamond-shaped nodes represent the 9 individually expressed HPV-31 proteins, and circles represent the 137 high-confidence interactors. HPV–human interactions are depicted in solid black lines, and manually curated human–human interactions are shown with broken gray lines. Select human complexes are highlighted by gray shadows and annotation. Interactors are colored based on detection in HEK293 (blue), Het-1A (orange), or both (see also Supplementary Table S2; Supplementary Figs. S1 and S2). Green rings around interactors indicate previously described HPV–human PPIs (see also Supplementary Table S1). Cancer genes are highlighted by a broken red ring around the respective human prey node.
Manon Eckhardt et al. Cancer Discov 2018;8:
©2018 by American Association for Cancer Research