1. In vitro time course assays for four renal selective compounds.
In vitro time course assays for four renal selective compounds. Renal line A498 was exposed to a wide range of concentrations for various times. Profiles of activity demonstrate that all agents confer near maximum activity with brief drug exposures (≤3 h) to similar drug concentrations (with the possible exception of NSC , which appears to require somewhat higher molar drug concentrations at the shorter intervals).
Susan D. Mertins et al. Clin Cancer Res 2001;7:
©2001 by American Association for Cancer Research