1. MICROENCAPSULATION Asst.Prof . kottam institute of pharmacy, A.P
SHUBHRAJIT MANTRY
Asst.Prof .
kottam institute of pharmacy, A.P

2. INTRODUCTION polymeric material.
Microencapsulation is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of
polymeric material.
The product obtained by this process is called as micro particles, microcapsules.
Particles having diameter between µm are known as micro particles or
microcapsules or microspheres.
Particles larger than 1000µm are known as Macro particles .

3. CLASSIFICATION OF MICROPARTICLE
Generally Micro particles consist of two components
a) Core material
b) Coat or wall or shell material.
1.Microcapsules: The active agent forms a core surrounded by an inert diffusion barrier.
2.Microspheres: The active agent is dispersed or dissolved in an inert polymer.

5. ADVANTAGES: To Increase of bioavailability To alter the drug release
To improve the patient’s compliance
To produce a targeted drug delivery
To reduce the reactivity of the core in relation to the outside environment
To decrease evaporation rate of the core material.
To convert liquid to solid form & To mask the core taste.

6. FUNDAMENTAL CONSIDERATION:
Microencapsulation
Core material Coating material Vehicle
Solid
Liquid
Polymers
Aqueous
Nonaqueous
Waxes
Resins
Proteins
Polysaccharides

7. APPLICATION OF MICROENCAPSULATION TECHNIQUES:

8. Microencapsulation : Applications
Chemistry
Printing & recording
Carbonless paper,
Adhesives
Pigments and
Fillers Catalysts
Medicine & Pharmacy & vetinary
Control release, Taste masking
Vectorisation
Artificial organs
single dose treatment
Food & feed
Aromas, Probiotics
Unsaturated oil,
Enzyme food processing
amino acid for cows
Agriculture
Fungicide – herbicide, Insect repellent, Biopesticide
Pigments and fillers
Artificial insemination
Biotechnology & environment
Continuous reactor,
Shear protection,
Reactor oxygenation
Consumer & diversified
Cosmetics,
detergents (enzymes),
sanitary (active, aromas)

9. MICROENCAPSULATION TECHNIQUES:

10. MICROENCAPSULATION TECHNIQUES:
Air suspension techniques( Wurster)
Coacervation process
Spray drying & congealing
Pan coating
Solvent evaporation
Polymerization
Extrusion
Single & double emulsion techniques
Supercritical fluid anti solvent method (SAS)
Nozzle vibration technology

11. Air Suspension Techniques( Wurster)
Microencapsulation by air suspension technique consist of the dispersing of solid, particulate core materials in a supporting air stream and the spray coating on the air suspended particles. Within the coating chamber, particles are suspended on an upward moving air stream. The design of the chamber and its operating parameters effect a recalculating flow of the particles through the coating zone portion of the chamber, where a coating material, usually a polymer solution, is spray applied to the moving particles.

12. Interesting, right?
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