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Pharmacodynamic evaluation of VT-464 and ABI in MR49F xenograft model.

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Presentation on theme: "Pharmacodynamic evaluation of VT-464 and ABI in MR49F xenograft model."— Presentation transcript:

1 Pharmacodynamic evaluation of VT-464 and ABI in MR49F xenograft model.
Pharmacodynamic evaluation of VT-464 and ABI in MR49F xenograft model. Fifteen xenograft-bearing mice were treated for 3 to 10 days with ABI 196 mg/kg twice daily (b.i.d), VT mg/kg twice daily, or vehicle and tumors were harvested. All mice were sacrificed approximately 3 hours after last dose (for details, see Materials and Methods). mRNA transcript levels of AR-related transcripts in tumor samples were evaluated with qRT-PCR relative to GAPDH (A). Western blot analysis for AR, PSA, and CYP17A1 levels demonstrates significant tumor heterogeneity between tumors from individual mice (B). Intratumoral drug levels for ABI and VT-464 as measured using LC-MS chromatography in triplicate (C). Steroid analysis results for androgens and upstream precursors (D). Paul J. Toren et al. Mol Cancer Ther 2015;14:59-69 ©2015 by American Association for Cancer Research

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