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European Urology Oncology

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Presentation on theme: "European Urology Oncology"— Presentation transcript:

1 European Urology Oncology
Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men  Thenappan Chandrasekar, Laura Gross, Leonard G. Gomella, Sarah E. Hegarty, Joon Yau Leong, Veda N. Giri  European Urology Oncology  DOI: /j.euo Copyright © 2019 European Association of Urology Terms and Conditions

2 Fig. 1 Flow of participant data and results (total cohort n=1435). FHX=family history; HBOC=hereditary breast and ovarian cancer; HCS=hereditary cancer syndrome; PCa=prostate cancer; Wh=Caucasian. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 European Association of Urology Terms and Conditions

3 Fig. 2 Examples of hereditary cancer syndromes with and without plausible genetic link to family member with prostate cancer (PCa). (A) Lynch syndrome—paternal side, linked to PCa. (B) Lynch syndrome—maternal side, not linked to PCa. (C) Hereditary PCa—paternal side. (D) Hereditary breast and ovarian cancer syndrome—maternal side, not linked to PCa. (E) Hereditary breast and ovarian cancer syndrome—maternal side, linked to PCa. Note that arrow points to proband. CA=cancer; COPD=chronic obstructive pulmonary disease. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 European Association of Urology Terms and Conditions


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