1. A protracted ketogenic diet increases radiation response in H292 lung cancer xenografts given conventional fractionated radiation.
A protracted ketogenic diet increases radiation response in H292 lung cancer xenografts given conventional fractionated radiation. H292 xenografts were grown in nude mice as in Fig. 2. Mice (6–8 per group) were treated with ketogenic diet for the entire treatment time and/or a 61.2 Gy total dose of radiation in 34 × 1.8 Gy fractions 3 times per week (M, W, F). The experiment was terminated 81 days after the beginning of ketogenic diet. A, tumor growth curve estimates showed that the ketogenic diet significantly enhances radiation response as assayed by tumor growth rates (P = ). B, pair wise group comparisons of Kaplan–Meier survival curves also showed that the ketogenic diet significantly enhanced radiation response (P = ).
Bryan G. Allen et al. Clin Cancer Res 2013;19:
©2013 by American Association for Cancer Research