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Oxygenated Lipids: A Mode to WiPE Out Inflammation?

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Presentation on theme: "Oxygenated Lipids: A Mode to WiPE Out Inflammation?"— Presentation transcript:

1 Oxygenated Lipids: A Mode to WiPE Out Inflammation?
Amelia E. Hochreiter-Hufford, Kodi S. Ravichandran  Immunity  Volume 36, Issue 5, Pages (May 2012) DOI: /j.immuni Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Sorting Apoptotic Cells for Clearance
Resident macrophages express the PS engulfment receptor Tim-4, which provides them recognition of apoptotic cells. MFG-E8 is the bridging molecule linking the phosphatidylserine (PS) exposed on apoptotic cells to integrin receptors on the surface of phagocytes. Inflammatory monocytes require MFG-E8 for recognition of apoptotic cells. Resident macrophages express 12/15-LO, allowing oxidation of phosphatidylethanolamine (oxPE). Resident macrophages are enriched with oxidized PE species, and this oxPE appears to sequester MFG-E8 and thereby interfere with the MFG-E8 dependent recognition of PS by inflammatory monocytes. Immunity  , DOI: ( /j.immuni ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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