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Fig. 4 Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro. Adenosine A2BR signaling promote osteogenic and inhibit.

Published byΘεοφάνης Κουρμούλης Modified over 5 years ago

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Presentation on theme: "Fig. 4 Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro. Adenosine A2BR signaling promote osteogenic and inhibit."— Presentation transcript:

1 Fig. 4 Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro.
Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro. (A and B) In vitro knockdown of adenosine A2BR using siRNA in primary mouse osteoprogenitor cells isolated from the BM for 2 days, followed by adenosine treatment (ADO; 30 μg/ml) for 7 or 14 days. Gene expression of (A) osteoblast-specific marker and (B) Opn. (C to F) In vitro knockdown of adenosine A2BR by siRNA in mouse mononuclear cells isolated from BM undergoing macrophage differentiation for 3 days, followed by osteoclast differentiation along with treatment of small-molecule adenosine (30 μg/ml) for 6 days. Gene expressions of (C) osteoclast transcription factor Nfatc1, (D) ACP5, and (E) CTSK. (F) TRAP staining. Second group from the left is no siRNA control, while the third group from the left involves control (scrambled) siRNA. Scale bar, 200 μm. n = 3. *P < 0.05, **P < 0.01, ***P < Yu-Ru V. Shih et al. Sci Adv 2019;5:eaax1387 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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