1. Drug interaction signatures for GIST and benign osteoma cell lines representing all combinatorial data compiled in a 9 × 9 drug matrix.
Drug interaction signatures for GIST and benign osteoma cell lines representing all combinatorial data compiled in a 9 × 9 drug matrix. Cells were treated with vehicle, FDA-approved drug, imatinib mesylate (IM) or the drug combination for 72 hours. A, color scale for percentage of the inhibition values of cell proliferation. Synergistic antiproliferative effects of FDA-approved drugs and imatinib mesylate in cells were assessed by CellTiter Glo assay in GIST-T1 (B), GIST 882 (C), GIST T1-10R cells (D), and in Hs. 919.T, a benign osteoid osteoma cell line (as a nonmalignant control; E) at 64 different drug ratios (concentrations range from 7.8 nmol/L to 1 μmol/L, half-dilutions for each drug). Right columns represent imatinib mesylate treatment alone and bottom rows represent FDA-approved drug treatment alone. Arrows indicate the increasing concentrations of each drug.
Ziyan Y. Pessetto et al. Mol Cancer Ther 2014;13:
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