Presentation is loading. Please wait.

Presentation is loading. Please wait.

Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency  Paul J. Maglione, MD,

Published byBram van der Linden Modified over 5 years ago

Similar presentations

Presentation on theme: "Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency  Paul J. Maglione, MD,"— Presentation transcript:

1 Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency  Paul J. Maglione, MD, PhD, Huaibin M. Ko, MD, Mary B. Beasley, MD, James A. Strauchen, MD, Charlotte Cunningham-Rundles, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 133, Issue 2, Pages (February 2014) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 The B-cell/T-cell ratio is variable in patients with CVID-associated PLH. A, Immunohistochemical staining of lungs for 2 representative patients demonstrating that the B-cell/T-cell ratio is variable among patients with CVID-associated PLH (original magnification ×40). B, Flow cytometric analysis of lungs from a representative patient with CVID-associated PLH. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Pulmonary lymphocytes are organized into B- and T-cell zones in patients with CVID-associated PLH. Hematoxylin-eosin and immunohistochemical staining for CD3 (T cells) and CD20 (B cells) is shown for 5 patients. Areas of B- and T-cell predominance are labeled as B and T, respectively. Magnification of images is ×40. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Ectopic follicles and germinal centers with localized proliferation in patients with CVID-associated PLH. Magnification is ×100 in patient 1, ×40 in patient 4, and ×200 in patient 5. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 CT scan of the chest of patient 1 before and 2 months after rituximab treatment. The CT scan demonstrated significant interval improvement after rituximab treatment, with resolution of ground-glass and solid opacities, as well as hilar and mediastinal adenopathy, with few persistent scattered nodules that were stable or smaller than those in the prior study. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency  Paul J. Maglione, MD,"

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency  Abdullah Alangari, MD,

LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency  Abdullah Alangari, MD,
Risk of an asthma exacerbation after bariatric surgery in adults

Risk of an asthma exacerbation after bariatric surgery in adults
Common variable immunodeficiency presenting with a large abdominal mass  Julie Wang, MD, Manuel Rodriguez-Davalos, MD, Gabriel Levi, MD, Bernhard Sauter,

Common variable immunodeficiency presenting with a large abdominal mass  Julie Wang, MD, Manuel Rodriguez-Davalos, MD, Gabriel Levi, MD, Bernhard Sauter,
Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement  Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement  Shradha Agarwal, MD, Charlotte Cunningham-Rundles,
Zeynep Yesim Kucuk, MD, Louis-Marie Charbonnier, PhD, Richard L

Zeynep Yesim Kucuk, MD, Louis-Marie Charbonnier, PhD, Richard L
Obstructive sleep apnea syndrome and inflammation

Obstructive sleep apnea syndrome and inflammation
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement  Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement  Shradha Agarwal, MD, Charlotte Cunningham-Rundles,
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,
Cynthia M. Magro, MD, Tracy L. Davis, MD, PhD, Drew J.B. Kurtzman, MD 

Cynthia M. Magro, MD, Tracy L. Davis, MD, PhD, Drew J.B. Kurtzman, MD 
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease  Paul T. King, MD, PhD, Steven Lim,

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease  Paul T. King, MD, PhD, Steven Lim,
Pathergy response to skin prick testing

Pathergy response to skin prick testing
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,

Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,
Volume 148, Issue 3, Pages e80-e85 (September 2015)

Volume 148, Issue 3, Pages e80-e85 (September 2015)
Selective early increases of bronchoalveolar CD8+ lymphocytes in a LEW rat model of hypersensitivity pneumonitis  Hal B. Richerson, MD, J.Daniel Coon,

Selective early increases of bronchoalveolar CD8+ lymphocytes in a LEW rat model of hypersensitivity pneumonitis  Hal B. Richerson, MD, J.Daniel Coon,
Chris M. Bacon, PhD, Sarah J. Wilkinson, MRes, Gavin P

Chris M. Bacon, PhD, Sarah J. Wilkinson, MRes, Gavin P
Nodular Lymphoid Hyperplasia of the Lung: A Very Rare Disease Entity

Nodular Lymphoid Hyperplasia of the Lung: A Very Rare Disease Entity

Similar presentations

Ads by Google