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Tensins: A New Switch in Cell Migration

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1 Tensins: A New Switch in Cell Migration
Ghassan Mouneimne, Joan S. Brugge  Developmental Cell  Volume 13, Issue 3, Pages (September 2007) DOI: /j.devcel Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Model for Alterations in Migration Induced by Tension Isoform Switch (A and B, left panels) In stationary MCF-10A cells, tensin and other adaptor proteins link β1 integrin to actin microfilament bundles (stress fibers) to form focal adhesions. (A and B, right panels) Tensin-switch induced by EGF causes the dissolution of stress fibers, a decrease in focal adhesions, and scattering of MCF10A cells. Cten competes with tensin 3 and other proteins for the binding to β1 integrin tail, uncoupling actin microfilaments from a large percentage of β1. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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