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Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency Babak Imani, M.D., Marinus J.C Eijkemans, M.Sc., Gerry H Faessen, B.Sc., Philippe Bouchard, M.D., Ph.D., Linda C Giudice, M.D., Ph.D., Bart C.J.M Fauser, M.D., Ph.D. Fertility and Sterility Volume 77, Issue 1, Pages (January 2002) DOI: /S (01)
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FIGURE 1 Distribution of 90 normogonadotropic anovulatory infertile women in four FSH response dose groups (75, 112.5, 150, or ≥187.5 IU/d) during ovulation induction by exogenous FSH in a low-dose, step-up regimen. (A), Ovarian response to previous clomiphene citrate therapy (clomiphene citrate resistance [CRA] or clomiphene citrate failure [CCF]). P<.001. (B), Cycle history (amenorrhea or oligomenorrhea). P<.001. Imani. Prediction of FSH threshold. Fertil Steril 2002. Fertility and Sterility , 83-90DOI: ( /S (01) )
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FIGURE 2 Scatter plot of the observed and predicted FSH response dose by the model during ovulation induction with exogenous FSH in a low-dose, step-up regimen. P5 = 5th percentile of predicted probability; P95 = 95th percentile of predicted probability. Imani. Prediction of FSH threshold. Fertil Steril 2002. Fertility and Sterility , 83-90DOI: ( /S (01) )
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FIGURE 3 Two initial screening variables in 90 normogonadotropic anovulatory infertile patients during ovulation induction with exogenous FSH in a low-dose, step-up regimen, by four FSH response dose groups (75, 112.5, 150, or >187.5 IU/d). Data are presented as box-and-whisker plots. The boxes encompass the 25th and the 75th percentiles, the horizontal lines represent median values, and the whiskers represent the 95% range of values. (A). Body mass index (BMI). P<.001, analysis of variance. (B), Free insulin-like growth factor-I (IGF-I). P<.004, analysis of variance. Imani. Prediction of FSH threshold. Fertil Steril 2002. Fertility and Sterility , 83-90DOI: ( /S (01) )
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