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The Tribble with APL: A New Road to Therapy

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1 The Tribble with APL: A New Road to Therapy
Ruaidhrí Carmody, Karen Keeshan  Cancer Cell  Volume 31, Issue 5, Pages (May 2017) DOI: /j.ccell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 TRIB3 Stabilizes PML-RARα to Promote Drug Resistance in APL
TRIB3 binds to PML-RARα and PML to inhibit all-trans retinoic acid (ATRA) and As2O3-induced SUMOylation(s), ubiquitination(s), and proteasomal degradation of PML-RARα. Depletion of TRIB3 or inhibition of TRIB3 and PML-RARα interaction results in the re-formation of PML nuclear bodies, p53-dependent senescence, and differentiation of APL cells. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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