1. Fig. 3 Long-term protective and functional benefit of photosynthetic therapy.
Long-term protective and functional benefit of photosynthetic therapy. Animals underwent myocardial IR injury and were randomized to saline control (n = 7), S. elongatus therapy (n = 10), or sham surgery (n = 7). (A) Serum troponin at 24 hours after injury was substantially reduced in the S. elongatus group compared with saline controls (P = 0.05), indicating ameliorated myocardial injury. (B) LV ejection fraction was increased in the S. elongatus group (P = 0.02) determined by cardiac MRI. (C) End-systolic volume was decreased in the S. elongatus–treated animals (P = 0.03), illustrating reduced pathologic remodeling. (D and E) Representative four-chamber cardiac MRI images. (F to H) S. elongatus therapy resulted in a greater slope of the LV pressure-volume relationship during inferior vena cava occlusion (P = 0.01), indicating enhanced ventricular contractility. All data reported as means ± SEM. *P < 0.05 using two-tailed unpaired Student’s t test.
Jeffrey E. Cohen et al. Sci Adv 2017;3:e
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