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Fig. 1 Architecture of PKA-C and locations of the Cushing’s syndrome mutations. Architecture of PKA-C and locations of the Cushing’s syndrome mutations.

Published byIngvild Møller Modified over 5 years ago

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Presentation on theme: "Fig. 1 Architecture of PKA-C and locations of the Cushing’s syndrome mutations. Architecture of PKA-C and locations of the Cushing’s syndrome mutations."— Presentation transcript:

1 Fig. 1 Architecture of PKA-C and locations of the Cushing’s syndrome mutations.
Architecture of PKA-C and locations of the Cushing’s syndrome mutations. (A) Structure of PKA-C [Protein Data Bank (PDB) ID: 1ATP] in complex with pseudo-substrate PKI depicting the location of Cushing’s mutations (yellow spheres) in relation to structural elements of the kinase. The E248Q mutation includes an additional deletion (del ), and the S212R mutation includes an insertion (insIILR) not depicted. (B) X-ray structure of PKA-CL205R (PDB ID: 4WB6) with the overlay of PKI5–24 (PKIWT from PDB ID: 1ATP) describing the architecture of the peptide binding site and steric clash between kinase (PKA-CL205R) and pseudo-substrate. (C) Structure of the R/C complex (PDB ID: 2QCS) depicting locations of Cushing’s mutations in relation to the pseudo-substrate inhibitory sequence of the R-subunit. (D) Primary sequence comparison of common regulators (RIα, RIIβ, and PKI) and peptide substrates of the catalytic subunit (Kemptide and VPS36). Caitlin Walker et al. Sci Adv 2019;5:eaaw9298 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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