1. Cost-effectiveness acceptability curves (CEAC) of tight control versus clinical management excluding (base case) and including absenteeism due to Crohn’s disease (CD) effects.
Cost-effectiveness acceptability curves (CEAC) of tight control versus clinical management excluding (base case) and including absenteeism due to Crohn’s disease (CD) effects. To illustrate the uncertainty surrounding incremental cost-effectiveness ratio (ICER) estimates, the CEACs depict the probability that the tight control   strategy (TC) strategy is preferred to the clinical management (CM) strategy across a range of cost-effectiveness ratios. Results are depicted for the analysis excluding absenteeism (hashed lines) and including absenteeism (solid grey line). Results are based on the probabilistic sensitivity analysis, which included 1000 second-order Monte Caro simulations in which model variables were simultaneously varied. The solid black vertical line indicates the £30 000 per quality-adjusted life-years (QALY) willingness-to-pay threshold commonly used as a benchmark in the UK. 57.9% of simulations were at the threshold when excluding absenteeism, indicating that TC was likely better value considering costs and QALYs than CM; 81.8% were below the threshold when including absenteeism, indicating TC was more probably good value versus CM in that scenario.
Remo Panaccione et al. Gut doi: /gutjnl
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