1. Ablation of Nf1 in HOXB7 lineage cells gives rise to diffuse cNF.
Ablation of Nf1 in HOXB7 lineage cells gives rise to diffuse cNF. A,H7;Nf1mut mouse model bearing diffuse cNF. B, Dissection of H7;Nf1mut mice showing that tumors are contained within the dermis. C, Patient with NF1 with diffuse cNF of the forearm. D, Biopsy of human diffuse cNF showing that tumor is contained within the dermis. E and F, Histologic characterization of murine (E) and human (F) diffuse cNF. Histochemistry was performed with X-Gal staining (HOXB7 lineage tracing in mice), H&E, insets (pigmented cells, arrows), Sirius red (collagen), toluidine blue (mast cells, arrowheads), and immunofluorescence with anti-S100β and anti-GAP43 (Schwann cell markers). Black and white scale bars, 50 μm. Blue scale bar, 1 mm.
Zhiguo Chen et al. Cancer Discov 2019;9:
©2019 by American Association for Cancer Research