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Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart  Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.

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Presentation on theme: "Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart  Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi."— Presentation transcript:

1 Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart 
Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi Paz, Rephael Mohr, Vladimir Yakirevich  The Annals of Thoracic Surgery  Volume 63, Issue 3, Pages (March 1997) DOI: /S (96) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

2 Fig. 1 Hemodynamic performance: peak systolic pressure. Results are shown as the percentage of baseline measurements after 15 minutes of stabilization. Before ischemia, all four groups demonstrated similar peak-systolic pressures. After ischemia, however, the control group had a significant deterioration in myocardial hemodynamics, whereas hearts given captopril either immediately before ischemia in the cardioplegic solution (Cardioplegia) or immediately after ischemia (Reperfusion) exhibited improved recovery. When captopril was given both in cardioplegia and during reperfusion (Card & Rep), peak systolic pressure was significantly better than in all three other groups (p < 0.001), and left ventricular hemodynamic deterioration was minimal. The Annals of Thoracic Surgery  , DOI: ( /S (96) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

3 Fig. 2 Hemodynamic performance: first derivative of rise in left ventricular pressure. Details and abbreviations are the same as in Fig. 1. The Annals of Thoracic Surgery  , DOI: ( /S (96) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

4 Fig. 3 Hemodynamic performance: pressure–time integral. Details and abbreviations are the same as in Fig. 1. The Annals of Thoracic Surgery  , DOI: ( /S (96) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

5 Fig. 4 Coronary flow before and after ischemia. Results are shown as the percentage of baseline measurements after 15 minutes of stabilization. Before ischemia, all four groups performed similarly. After ischemia, hearts treated with captopril had a significantly better recovery and viability compared with the control group in terms of coronary flow (p < 0.001). Hearts treated with captopril both before and after ischemia (Card & Rep) had the best results, and when this group was compared with the control group, analysis of variance for drug effect was most prominent (p < 0.001). (Cardioplegia = hearts given captopril in cardioplegic solution; Reperfusion = hearts given captopril during reperfusion.) The Annals of Thoracic Surgery  , DOI: ( /S (96) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

6 Fig. 5 Oxygen consumption before and after ischemia. Details and abbreviations are the same as in Fig. 4. The Annals of Thoracic Surgery  , DOI: ( /S (96) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

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