1. Understanding the Expanding Armamentarium for GIST

2. Overview of GIST

3. Workup of Suspected GIST

4. Initial Treatment of Metastatic GIST

5. First-Line GIST Treatment: Imatinib

6. Second-Line GIST Treatment: Sunitinib

7. Third-Line GIST Treatment: Regorafenib

8. Investigational Approaches: Crenolanib

9. CrenoGIST: Phase 3 Trial of Crenolanib in D842V-Mutated GIST

10. Investigational Approaches: Avapritinib

11. VOYAGER: Phase 3 Trial of Avapritinib in Third- and Fourth-Line GIST

12. Investigational Approaches: Ripretinib

13. Phase 3 Trials of Ripretinib in GIST

14. Other Novel Strategies

15. Key Takeaways

16. Abbreviations

17. Abbreviations (cont)