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Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood  Adnan Custovic, MD, PhD, Lars Soderstrom,

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Presentation on theme: "Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood  Adnan Custovic, MD, PhD, Lars Soderstrom,"— Presentation transcript:

1 Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood  Adnan Custovic, MD, PhD, Lars Soderstrom, MSc, Staffan Ahlstedt, PhD, Peter D. Sly, MD, PhD, Angela Simpson, MD, PhD, Patrick G. Holt, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 6, Pages (June 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Cat allergen–specific IgE and rFel d 1–specific IgG and IgG4 antibody levels among children with and without current wheeze in the UK and Australian cohorts. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Excellent correlation between IgE antibodies of whole-allergen extract for cat and IgE antibodies to rFel d 1. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 A and B, Fitted predicted probability for current wheeze at a given cat-specific IgE value and rFel d 1–specific IgG value derived from the multivariate logistic regression analysis for children in the UK (Fig 3, A) and Australia (Fig 3, B). C and D, Fitted predicted probability for current wheeze at a given cat-specific IgE value and rFel d 1–specific IgG4 value derived from the multivariate logistic regression analysis for children in the UK (Fig 3, C) and Australia (Fig 3, D). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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